Dianthus Therapeutics Signs Exclusive License Deal With Leads Biolabs For DNTH212, A Phase 1 Ready Bifunctional Autoimmune Drug

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Dianthus Therapeutics, Inc. - Common Stock

DNTH

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DNTH212 is a bifunctional fusion protein targeting plasmacytoid dendritic cell (pDC) BDCA2 to reduce Type 1 interferon production, while simultaneously inhibiting BAFF/APRIL to suppress B cell function
Demonstrated superior inhibition of pDCs vs. litifilimab in vitro and superior Ig reductions vs. povetacicept in NHPs highlight the potential for improved clinical benefit in severe autoimmune diseases
DNTH212 has the potential to be a first line biologic in multiple autoimmune disorders with patient-friendly S.C. self-administration and Q4W or less frequent dosing
IND cleared by FDA in September 2025 and expected to clear in China in Q4'25. Phase 1 study of DNTH212 expected to initiate in Q4'25 with top-line results in healthy volunteers in 2H'26
Pro forma estimated cash of ~$525 million; reaffirms runway into 2028
Investor conference call and webcast to be held today at 8:00 a.m. ET

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