Atea initiates first-in-human Phase 1 trial of AT-587 for hepatitis E virus

Atea Pharmaceuticals, Inc.

Atea Pharmaceuticals, Inc.

AVIR

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  • Atea Pharmaceuticals initiated a first-in-human Phase 1 trial of AT-587 for hepatitis E virus, a disease with no approved therapies.
  • Randomized, double-blind, placebo-controlled study in healthy volunteers to assess safety, tolerability, pharmacokinetics, food effect, SAD, MAD.
  • Preclinical data cited 30- to 150-fold higher in vitro potency versus sofosbuvir and ribavirin; in vivo activity shown in HEV genotype 3 model.
  • Program positions AT-587 as a potential first-in-class oral HEV treatment, targeting immunocompromised patients at risk of chronic infection.


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