BioArctic says AAIC 2026 data show Leqembi subcutaneous autoinjector matches IV efficacy, safety in early Alzheimer’s

  • BioArctic partner Eisai presented AAIC 2026 data indicating Leqembi subcutaneous autoinjector could match IV efficacy, safety in early Alzheimer’s disease.
  • Once-weekly 500 mg SC dosing showed bioequivalence to IV initiation, with 104% exposure ratio (90% CI: 99.1%-109%).
  • Data linked amyloid reduction, CDR-SB outcomes, ARIA-E risk to drug exposure rather than administration route.
  • Safety broadly aligned with IV; injection-site reactions mainly local; anti-drug antibodies 1.4% with no neutralizing antibodies observed.
  • Findings support a fully subcutaneous pathway, including switching between IV and SC, potentially expanding access via at-home administration.


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