BridgeBio posts ESC-HF presentation on acoramidis impact on NT-proBNP in ATTR-CM
BridgeBio Pharma
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- BridgeBio published medical research presentation reporting a post hoc subgroup analysis from Phase 3 ATTRibute-CM evaluating acoramidis impact on NT-proBNP through Month 30 versus placebo in ATTR-CM.
- Acoramidis blunted NT-proBNP rise by about 50% across pre-specified subgroups, including advanced disease; treatment effects favored acoramidis in all subgroups assessed (all p<0.001).
- Month 30 analysis included 595 randomized participants; 45% of acoramidis recipients with paired data had net NT-proBNP decrease versus 9% on placebo.
- In participants without concomitant tafamidis, median NT-proBNP change at Month 30 was 86 pg/mL for acoramidis alone versus 1,135 pg/mL for placebo alone.
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