BridgeBio posts infigratinib achondroplasia trial presentation

BridgeBio Pharma

BridgeBio Pharma

BBIO

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  • BridgeBio published results from the Phase 3 PROPEL 3 trial of oral infigratinib in children with achondroplasia.
  • Primary endpoint met: annualized height velocity increased at week 52; LS mean difference vs placebo 1.74 cm/year (95% CI 1.31-2.17); p<0.0001.
  • Height z-score improved at week 52; LS mean difference vs placebo 0.32 (96% CI 0.23-0.41); p<0.0001.
  • Safety profile described as well-tolerated; treatment-emergent adverse events balanced vs placebo; no treatment-related serious adverse events or discontinuations reported.


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