Caribou says off-the-shelf CAR-T vispa-cel posts 82% response rate in second-line LBCL study

Caribou Biosciences, Inc.

Caribou Biosciences, Inc.

CRBU

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  • Caribou Biosciences reported long-term Phase 1 data for its off-the-shelf CD19 CAR-T candidate vispa-cel in second-line large B cell lymphoma.
  • The results were scheduled for an oral presentation at the EHA 2026 meeting on June 12.
  • Patients showed durable tumor responses, supporting the view that a single-dose, readily available cell therapy could compete with autologous CAR-T outcomes.
  • Safety remained broadly manageable, with no signals that would block outpatient use, though serious events included rare treatment-related deaths.
  • The update underpinned plans for the ANTLER-3 randomized Phase 3 study in about 250 patients, with progression-free survival as the primary endpoint.


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