Circio partners with GenAssist on circVec-enhanced AAV gene therapy research for muscle diseases

  • Circio entered a research collaboration with GenAssist to develop circVec-enhanced AAV vectors for muscle diseases, in vivo cell therapy.
  • Program targets lower-dose systemic gene therapy by combining circVec expression with GenAssist tissue-specific, liver de-targeted AAV capsids, promoters.
  • Parties will also assess in vivo CAR-T candidates using GenAssist T-cell targeting with circVec, advancing successful constructs toward preclinical nomination.
  • Circio cited up to 50-fold higher in vivo gene expression from AAV vectors using its circVec circular RNA platform.


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