• Ionis Pharmaceuticals CEO and director Brett P. Monia sold 4,536 shares of common stock in transactions dated May 13-14.
• Sales were executed at weighted average prices of $78.01 and $78.68.
• Monia acquired 4,536 shares via option exercises at $32.6 per share.
• Directly held common stock position stood at 242,662 shares after the transactions.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission (Ref. ID: 0000874015-26-000185), on May 15, 2026, and is solely responsible for the information contained therein.