• Ionis Pharmaceuticals director Spencer R. Berthelsen exercised stock options for 8,000 shares at USD 24.42 on June 15, 2026.
• He sold 8,000 shares at USD 73.49 the same day.
• Directly held common shares totaled 156,013 after the transactions.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission (Ref. ID: 0000874015-26-000207), on June 16, 2026, and is solely responsible for the information contained therein.