Lundbeck releases investor presentation on bocunebart migraine prevention data

  • H. Lundbeck A/S published an investor presentation on bocunebart, positioning PACAP inhibition as a new mechanism for severe migraine prevention alongside Vyepti.
  • PROCEED Phase 2b met its primary endpoint for one IV dose, cutting monthly migraine days by 4.24 vs 2.86 for placebo over weeks 1-12.
  • Other doses showed numerical reductions versus placebo but missed statistical significance; safety profile was generally well tolerated with no new signals flagged.
  • Post-hoc pooled analysis in chronic migraine showed 5.9 fewer monthly migraine days with bocunebart vs 3.6 with placebo at week 12.
  • Phase 3 planning is underway, with regulatory interactions cited; next program update is slated for 2H 2026.


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