The Fed’s balance sheet is back in focus, and for large US banks, that can reshape how money moves through the system. With Kevin Warsh at the helm signaling support for a leaner Fed balance sheet over time, investors are weighing what tighter financial conditions, changing liquidity rules, and a “business-as-usual” stance today might mean for major banking stocks. This article highlights 3 US large-cap bank stocks from our screener that are exposed to these policy shifts, helping you decide whether they deserve a closer look or a place on your watchlist as the Fed’s next chapter unfolds.

Old National Bancorp (ONB)

Overview: Old National Bancorp is a US regional bank that offers a full range of consumer and commercial services, from everyday deposit accounts and loans to digital banking, cards, and capital markets support for businesses. It also runs sizeable wealth management, private banking, and community development activities across its Midwest footprint, combining traditional lending with fee-based services like investment advisory, brokerage, and foreign currency.

Operations: Old National Bancorp generates about US$2.5b in revenue from Community Banking activities, all of it in the United States.

Market Cap: US$9.6b

Old National Bancorp sits at the center of the Fed balance sheet story, with a US regional footprint, a 5-Star Bauer Financial rating for strength, and a community banking model that could benefit if liquidity rules are relaxed and funding becomes more flexible. Earnings growth has been solid, the dividend is reliable, and management is leaning into fee income and commercial banking appointments while using hedges and a neutrally positioned balance sheet to manage interest rate swings. At the same time, exposure to commercial real estate, a relatively low but improving ROE, and a higher P/E than some peers mean investors still need to judge whether the quality story justifies the current pricing and analyst expectations.

Old National Bancorp’s mix of solid earnings, a 5-Star Bauer rating, and a richer P/E hints at a quality story that many may still be pricing on autopilot. Review the DCF valuation analysis for Old National Bancorp to see what the market might be missing.

Cadence Bank (CADE)

Overview: Cadence Bank is a regional US bank headquartered in Tupelo, Mississippi, offering a full suite of commercial and community banking services, mortgages, and wealth management solutions to individuals, businesses, governments, and non-profits. Alongside traditional lending and deposit products, Cadence Bank provides trust, investment management, retirement planning, and estate services across its multi state footprint.

Operations: Cadence Bank generates about US$1.9b in revenue, all from customers in the United States.

Market Cap: US$7.9b

Cadence Bank is part of the large cap bank group and offers exposure to Sunbelt markets together with a mix of commercial lending, fee income, and wealth services, supported by capital and liquidity metrics described as solid. For investors following discussions about how Kevin Warsh’s leaner Fed balance sheet could tighten financial conditions, Cadence’s emphasis on noninterest bearing deposits, cost reduction, and digital investments may be of interest. At the same time, insider selling, an 8.7% ROE, and margin pressure highlight that execution remains important. The combination of dividends, earnings quality, and measured expansion through acquisitions and technology spending may make Cadence Bank a candidate for further research as Fed policy continues to influence the banking sector.

Cadence Bank’s mix of Sunbelt exposure, noninterest bearing deposits, and cost control feels like an underappreciated setup for the next Fed chapter. The full story sits inside the analysis report for Cadence Bank

Huntington Bancshares (HBAN)

Overview: Huntington Bancshares is a large US regional bank that offers everyday banking, mortgages, small business lending, equipment finance and wealth management, delivered through branches, ATMs, online and mobile platforms across its core Midwest base and newer high growth markets like Texas. It complements traditional loans and deposits with services such as payments, treasury management, investment management, trust and brokerage for consumers, middle market clients and government entities.

Operations: Huntington Bancshares generates about US$8.3b in revenue, with roughly US$3.0b from Commercial Banking and US$5.7b from Consumer and Regional Banking, all in the United States, partly offset by a loss reported in Treasury / Other.

Market Cap: US$35.2b

Huntington Bancshares stands out in the large cap bank group because it combines a growing footprint in Texas and other faster growing markets with a long history in the Midwest, a 3.58% dividend yield and a clear plan to capture cost and revenue synergies from recent acquisitions. Management is actively managing interest rate risk with hedges, is targeting 18% to 19% tangible ROE and has committed to meaningful buybacks. At the same time, the stock carries a higher P/E than many peers and has seen shareholder dilution alongside pressure on margins and ROE. For investors watching how Kevin Warsh’s leaner Fed balance sheet and possible liquidity rule changes affect regional banks, the way Huntington balances growth, capital returns and risk controls is a key area of focus.

Huntington Bancshares’ mix of Texas growth, Midwest roots, and capital return plans looks like it could be telling a bigger story than the headline P/E suggests, and the real kicker may sit in the analyst forecasts for Huntington Bancshares

The three banks in this article are only a starting point, and the full US Large-Cap Bank Stocks screener reveals 31 more large cap US banking stocks with similarly compelling stories around capital strength, earnings mix, and exposure to the Fed balance sheet theme. Use Simply Wall St to identify and analyze the specific catalysts, risk flags, and business narratives that matter to you so you can focus on the highest conviction ideas in this part of the financial sector.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.