March 3 (Reuters) - Wall Street's main indexes opened sharply lower on Tuesday as investors braced for the impact of a widening conflict in the Middle East on inflation and global trade.

The Dow Jones Industrial Average .DJI fell 411.7 points, or 0.84%, at the open to 48,493.11. The S&P 500 .SPX fell 81.4 points, or 1.18%, at the open to 6,800.26​, while the Nasdaq Composite .IXIC dropped 456.5 points, or 2.01%, to 22,292.37 at the opening bell.