Wall Street's main indexes fell on Wednesday as growing tensions in the Middle East dented risk sentiment, with investors also focused on earnings to gauge the impact of inflation and high interest rates on businesses. .N

At 11:45 ET, the Dow Jones Industrial Average .DJI was down 0.50% at 33,827.35. The S&P 500 .SPX was down 0.76% at 4,340.13 and the Nasdaq Composite .IXIC was down 0.90% at 13,411.998.

The top three S&P 500 .PG.INX percentage gainers:
** Nasdaq Inc NDAQ.O, up 5.6%
** Dexcom DXCM.O, up 3.9%
** Valero Energy VLO.N, up 3.2%

The top three S&P 500 .PL.INX percentage losers:
** Albemarle ALB.N, down 9.9%
** United Airlines UAL.O, down 8.4%
** Bio-Rad Labs BIO.N, down 8.1%

The top three NYSE .PG.N percentage gainers:
** Spirit AeroSystems Holdings SPR.N, up 23.6%
** Houston American Energy HUSA.N, up 11.8%
** Indonesia Energy INDO.N, up 11.1%

The top two NYSE .PL.N percentage losers:
** Enviva Inc EVA.N, down 13.3%
** Li-Cycle Holdings LICY.N, down 11.9%

The top two Nasdaq .PG.O percentage gainers:
** Falcon's Beyond Global FBYDP.O, up 154.4%
** Sigma Additive Solutions SASI.O, up 65.3%

The top two Nasdaq .PL.O percentage losers:
** Nuzee Inc Ord NUZE.O, down 42.3%
** Bridger Aerospace Group BAER.O, down 26.6%

** Morgan Stanley MS.N: down 7.9%
BUZZ-Falls after Q3 profit drops on slow M&A activitynL4N3BO39X

** Goldman Sachs GS.N: down 2.0%
BUZZ-Street View: Return on equity, writedowns in focus nL4N3BO3J4

** Ultragenyx Pharma RARE.O: down 10.9%
BUZZ-Slides after stock offering launch nL1N3BO1FP

** SolarEdge SEDG.O: down 5.2%
BUZZ-Falls after PT cuts on weak solar demand nL4N3BO3KI

** Procter & Gamble PG.N: up 1.9%
BUZZ-Rises after Q1 beat nL4N3BO3KM

** Winnebago Industries WGO.N down 2.7%
BUZZ-Falls on Q4 revenue miss nL4N3BO3P4

** Bridger Aerospace BAER.O down 26.6%
BUZZ-Dives after launching $70 mln stock offering nL1N3BO1NM

** Nikola NKLA.O down 7.1%
BUZZ-Down as brokerage expects no deliveries in Q3 nL4N3BO3EG

** SeaStar Medical ICU.O up 44.9%
BUZZ-Jumps on FDA's 'breakthrough' tag for liver disease treatment device nL4N3BO3UK

** Lululemon LULU.O down 1.1%
BUZZ-Dips in first day of trading in S&P 500 nL1N3BO1UK

** Nvidia NVDA.O: down 3.6%

BUZZ-Extends losses on lingering concerns about US curbs nL4N3BO2F3

** United Airlines Holdings UAL.O: down 8.4%

BUZZ-Drops on downbeat profit forecast nL4N3BO2GC

** Chevron CVX.N: up 1.1%

** Exxon Mobil XOM.N: up 1.2%

** Occidental Petroleum OXY.N: up 1.8%

** Devon Energy DVN.N: up 0.9%

BUZZ-U.S. energy firms edge higher as oil spikes on escalation in Middle East strife nL4N3BO2FT

** Interactive Brokers Group IBKR.O: down 4.7%

BUZZ-Falls on tempered account growth forecast nL4N3BO2OW

** Freeline Therapeutics Holdings FRLN.O: up 11.6%

BUZZ-Rises on proposal for acquisition of all outstanding shares nL4N3BO2VZ

** Ardelyx ARDX.O: up 15.2%
BUZZ-Gains as US FDA greenlights kidney disease-related drug nL4N3BO30C

** Johnson & Johnson JNJ.N: down 1.9%
BUZZ-Street View: 2024 outlook looks hazy nL4N3BO1V4

** Southwestern Energy SWN.N: up 1.9%
BUZZ-Rises on potential acquisition by Chesapeake nL4N3BO2Z8

** Abbott Laboratories ABT.N: up 2.9%
BUZZ-Rises as Q3 profit beats estimates on sales of devices, diagnostics nL4N3BO2JT

** Enphase ENPH.O: down 4.3%
BUZZ-Street View: Enphase to face tough 2023 with high inventory, Tesla competition nL4N3BO2Y2

** Spirit AeroSystems SPR.N: up 23.6%
BUZZ-Announces agreement with Boeing; shares rise nL4N3BO37T

** Visa V.N: down 1.1%

** Mastercard MA.N: down 1.3%
BUZZ-Slip on report Fed to lower debit-card swipe fees nL4N3BO379

** Roku ROKU.O: down 6.4%
BUZZ-Slips as Wells Fargo cuts PT on soft advertising trends nL1N3BO15O

** SQM SQM.N: down 6.6%
BUZZ-Drops after BofA cuts to 'underperform' nL4N3BO39K

The 11 major S&P 500 sectors:

Communication Services	.SPLRCL	down 0.52%
Consumer Discretionary	.SPLRCD	down 1.62%
Consumer Staples	.SPLRCS	up 0.33%
Energy	.SPNY	up 1.09%
Financial	.SPSY	down 1.23%
Health	.SPXHC	down 0.43%
Industrial	.SPLRCI	down 1.55%
Information Technology	.SPLRCT	down 0.56%
Materials	.SPLRCM	down 2.11%
Real Estate	.SPLRCR	down 1.67%
Utilities	.SPLRCU	down 0.90%

(Compiled by Christy Santhosh in Bengaluru)

((christy.santhosh@thomsonreuters.com))