• CareDx, Inc. recently reported pivotal clinical validation results from its ACROBAT study for AlloHeme, an AI- and NGS-based blood test that predicts relapse in acute myeloid leukemia and myelodysplastic syndromes after allogeneic hematopoietic cell transplant, showing high sensitivity, specificity, and earlier relapse detection than traditional methods.
• This successful validation of AlloHeme marks a meaningful broadening of CareDx’s Transplant+ platform beyond solid organ transplantation into hematology-oncology and cell therapy monitoring, potentially widening its clinical footprint and revenue mix over time.
• We will now examine how AlloHeme’s early-relapse detection data and planned commercialization pathway may influence CareDx’s broader investment narrative.

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CareDx Investment Narrative Recap

To own CareDx, you need to believe its transplant-focused testing and software platform can keep growing despite reimbursement uncertainty and product concentration around AlloSure and HeartCare. The AlloHeme ACROBAT data adds a new hematology-oncology pillar to this story, but does not meaningfully change that the key near term swing factor is still how new LCD reimbursement policies affect core transplant surveillance revenue, and the related risk of pricing and volume pressure.

The most relevant related development is CareDx’s February 3 announcement that the full 24 month ACROBAT AlloHeme data would be presented at the 2026 Tandem Meetings. That disclosure framed AlloHeme as part of a broader Transplant+ expansion, which sits alongside more traditional catalysts such as execution against the US$365 million to US$375 million 2025 revenue guidance and ongoing share repurchases as the market reassesses reimbursement and earnings durability.

Yet even with AlloHeme’s progress, investors should be aware that reimbursement policy shifts could still...

CareDx's narrative projects $485.8 million revenue and $78.0 million earnings by 2028. This requires 12.5% yearly revenue growth and about a $19.9 million earnings increase from $58.1 million today.

Uncover how CareDx's forecasts yield a $23.00 fair value, a 17% upside to its current price.

Exploring Other Perspectives

Some of the lowest ranked analysts were already cautious, expecting about 12.3% annual revenue growth and no profitability over three years, and see reimbursement and pricing pressure as much more limiting than the consensus view, so this new AlloHeme data could eventually shift their narrative in either direction.

Explore 3 other fair value estimates on CareDx - why the stock might be worth over 10x more than the current price!

Build Your Own CareDx Narrative

Disagree with existing narratives? Create your own in under 3 minutes - extraordinary investment returns rarely come from following the herd.

• A great starting point for your CareDx research is our analysis highlighting 3 key rewards and 2 important warning signs that could impact your investment decision.
• Our free CareDx research report provides a comprehensive fundamental analysis summarized in a single visual - the Snowflake - making it easy to evaluate CareDx's overall financial health at a glance.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.