Biotech is back – and it's playing for keeps. President Donald Trump's second-term policies have unleashed a staggering ~$350 billion surge in U.S.-based pharmaceutical and biotech investments, from domestic manufacturing to cutting-edge R&D. For investors, it's a rare opportunity: major drugmakers are expanding fast, and some could be poised to deliver serious portfolio gains.

• Track biotech stocks via XBI ETF here.

Big Names, Bigger Moves

Johnson & Johnson (NYSE:JNJ) leads the charge with a $55 billion investment in U.S. manufacturing, while AstraZeneca PLC (NASDAQ:AZN) is plowing $50 billion into research and production. Novartis AG (NYSE:NVS) is building or expanding 10 U.S. facilities with $23 billion, and Bristol-Myers Squibb Co (NYSE:BMY) is committing $40 billion over the next five years.

Even Eli Lilly And Co (NYSE:LLY) is stepping up with $27 billion to more than double domestic manufacturing capacity. These moves aren't just numbers on a spreadsheet – they're job creators, innovation engines, and revenue boosters all rolled into one.

Read Also: Novartis To Expand Heart Drug Portfolio With $1.4 Billion Tourmaline Bio Acquisition

Where Investors Can Look

ETF investors may want to peek at SPDR S&P Biotech ETF (NYSE:XBI) or iShares Nasdaq Biotechnology ETF (NASDAQ:IBB), which house these giants.

Individual stock investors can focus on J&J, Novartis, Eli Lilly, AstraZeneca, and BMS as companies likely to benefit from a government-fueled capital boom. With U.S. production and domestic supply chains now a top priority, these firms could see long-term gains both in the lab and on the balance sheet.

Why This Matters

The scale of this investment is unprecedented. By combining regulatory support, tax incentives, and industrial encouragement, Trump's policies are turbocharging America's biotech sector.

For investors, the takeaway is clear: betting on this wave could mean getting in on the ground floor of a domestic pharmaceutical renaissance.

Read Next:

• Ozempic Is The New Botox And Big Pharma Is Printing Billions

Photo: jittawit21/Shutterstock