Results published in peer-reviewed journal, Clinical Cancer Research

 

Study validates DetermaIO's utility in identifying breast cancer patients most likely to benefit from atezolizumab

DetermaIO targets a multi-billion-dollar addressable market in oncology diagnostics

IRVINE, Calif., Oct. 08, 2024 (GLOBE NEWSWIRE) -- Oncocyte Corp. (NASDAQ:OCX), a diagnostics technology company, announced the peer-reviewed publication of positive data related to its proprietary gene expression test, DetermaIO™.

The NeoTRIP Phase 2 clinical trial (NCT002620280) randomized patients with triple-negative breast cancer (TNBC) to receive neoadjuvant carboplatin and nab-paclitaxel (chemotherapies to shrink tumors), with or without the immunotherapy, atezolizumab. As a secondary point of interest in the study, Oncocyte's DetermaIO test was among several established biomarkers and gene signatures assessed for its ability to predict which patients with early stage TNBC are most likely to benefit from the immunotherapy. The study was performed in collaboration with the Michelangelo Foundation for Cancer Research, a well-regarded independent scientific organization based in Milan.

There is an unmet need in TNBC for biomarkers that are predictive of the selective benefit of immune checkpoint inhibitors, which DetermaIO aims to address. Only DetermaIO was both statistically significant and predictive of a pathologic complete response (pCR) among the various biomarkers assessed. In the NeoTRIP clinical trial, patients who tested positive by the DetermaIO assay (IO+) had a significantly higher pathologic complete response (pCR) rate when treated with atezolizumab plus chemotherapy (69.8%) compared to chemotherapy alone (46.9%). In contrast, patients who tested negative by the DetermaIO assay (IO-) did not show a significant improvement in pCR rates with atezolizumab plus chemotherapy (44.6%) compared with chemotherapy alone (49.2%), highlighting DetermaIO's predictive power for the selective benefit of immune checkpoint inhibitors, or ICIs.