Alnylam initiates Phase 2 trial of mivelsiran in Down syndrome-associated Alzheimer’s disease

Alnylam Pharmaceuticals, Inc

Alnylam Pharmaceuticals, Inc

ALNY

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  • Alnylam initiated a Phase 2 trial of mivelsiran in Down syndrome-associated early-stage Alzheimer’s disease, expanding its clinical Alzheimer’s program.
  • Enrollment completed in the Phase 2 cAPPricorn-1 study of mivelsiran in cerebral amyloid angiopathy; initial results expected in 2028.
  • Phase 1 mivelsiran data in early-onset Alzheimer’s showed no increased ARIA signal; mean maximum CSF reductions reached 89.9% for sAPPβ.


Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Alnylam Pharmaceuticals Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20260715865310) on July 15, 2026, and is solely responsible for the information contained therein.

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