May 7 (Reuters) - Wall Street's main indexes rose on Wednesday, boosted by megacap growth stocks and as corporate results rolled in, while investors awaited commentary from Federal Reserve policymakers for clues on the economy's health. .N

At 11:30 EDT, the Dow Jones Industrial Average .DJI was down 0.16% at 49,830.33.The S&P 500 .SPX was up 0.10% at 7,372.16, and the Nasdaq Composite .IXIC was up 0.45% at 25,954.10.

The top three S&P 500 .PG.INX percentage gainers:

** Datadog Inc (Pre-Reincorporation) DDOG.OQ, up 29.7%

** Fortinet Inc FTNT.OQ, up 23.5%

** Axon Enterprise Inc AXON.OQ, up 10.6%

The top three S&P 500 .PL.INX percentage losers:

** Zoetis Inc ZTS.N, down 23.0%

** Tapestry Inc TPR.N, down 10.2%

** Akamai Technologies Inc AKAM.OQ, down 7.4%

The top three NYSE .PG.N percentage gainers:

** agilon health inc AGL.N, up 104.7%

** Octave Specialty Group Inc OSG.N, up 40.0%

** Aspen Aerogels Inc ASPN.N, up 28.3%

The top three NYSE .PL.N percentage losers:

** Planet Fitness Inc PLNT.N, down 32.6%

** Shake Shack Inc SHAK.N, down 29.0%

** Amprius Technologies Inc AMPX.N, down 26.9%

The top three Nasdaq .PG.O percentage gainers:

** Global Engine Group Holding Ltd GLE.OQ, up 87.5%

** Rackspace Technology Inc RXT.OQ, up 84.1%

** Sobr Safe Inc SOBR.OQ, up 73.3%

The top three Nasdaq .PL.O percentage losers:

** GD Culture Group Ltd GDC.OQ, down 86.8%

** OneConstruction Group Ltd ONEG.OQ, down 80.3%

** enGene Therapeutics Inc ENGN.OQ, down 78.9%

** Snap Inc SNAP.N:
BUZZ - Falls on ad revenue hit from Mideast conflict, tepid North America growth nL4N41K0N2

** Beyond Meat Inc BYND.O:
BUZZ - Falls premarket on weak Q2 sales forecast nL6N41K0IY

** Fortinet Inc FTNT.O:
BUZZ - Soars after hiking annual forecasts nL4N41K0PC

** Catalyst Pharmaceuticals Inc CPRX.O:
BUZZ - Climbs on $4.1 billion buyout deal nL4N41K0Q6

** Whirlpool Corp WHR.N:
BUZZ - Misses Q1 revenue estimates, suspends dividend, shares fall nL6N41K0OI

** DoorDash Inc DASH.O:
BUZZ - Climbs after forecasting Q2 order value above estimates nL6N41K0ML

** Johnson Controls International PLC JCI.N:
BUZZ - RBC lifts Johnson Controls PT after upbeat 2026 profit forecast nL4N41K0WQ

** Tapestry Inc TPR.N:
BUZZ - Up after raising annual sales, profit forecasts nL6N41K0NX

** Cytokinetics Inc CYTK.O:
BUZZ - Dips after boosted $700 mln stock sale for heart drug nL6N41K0O9

** Zoetis Inc ZTS.N:
BUZZ - Slumps after trimming full-year forecast, Q1 miss nL4N41K1FO

** McDonald's Corp MCD.N:
BUZZ - Rises after Q1 revenue, profit beat nL6N41K0NM

** Peloton Interactive Inc PTON.O:
BUZZ - Rises after quarterly revenue beats estimates nL4N41K10Y

** MGE Energy Inc MGEE.O:
BUZZ - Falls on pricing $250 mln stock offering nL6N41K0QA

** Sarepta Therapeutics Inc SRPT.O:
BUZZ - Falls on lower quarterly sales for gene therapy nL4N41K11W

** Americold Realty Trust Inc COLD.N:
BUZZ - Shares rise after upbeat 2026 forecast, EQT joint venture nL4N41K133

** Agilon Health Inc AGL.N:
BUZZ - Jumps after raising outlook, beating quarterly profit views nL4N41K131

** Insmed Inc INSM.O:
BUZZ - Falls after lung disease treatment misses sales expectations nL4N41K14U

** Becton Dickinson and Co BDX.N:
BUZZ - Gains after raising annual profit forecast nL4N41K1LZ

** RXO Inc RXO.N:
BUZZ - Jumps after quarterly revenue beats estimates nL4N41K165

** Tempus AI Inc TEM.O:
BUZZ - Slips on $350 mln convertible debt deal plans nL6N41K0R1

** Blue Owl Capital Corp OBDC.N:

** Blue Owl Technology Finance Corp OTF.N:
BUZZ - Private credit funds slip after dividend cuts nL6N41K0RG

** MannKind Corp MNKD.O:
BUZZ - Falls after quarterly revenue miss nL4N41K183

** Chevron Corp CVX.N:

** Exxon Mobil Corp XOM.N:

** Occidental Petroleum Corp OXY.N:

** Devon Energy Corp DVN.N:
BUZZ - US energy stocks slip as crude falls on hopes of US-Iran truce nL4N41K18F

** On Semiconductor Corp ON.O:
BUZZ - Shares down after $1.3 bln convertible bond sale nL6N41K0SQ

** Cognex Corp CGNX.O:
BUZZ - Rises after upbeat Q2 forecast nL6N41K0TB

** Vistra Corp VST.N:
BUZZ - Climbs after swinging to Q1 profit nL6N41K0T5

** Datadog Inc DDOG.O:
BUZZ - Surges on Q1 beat, annual guidance raise nL4N41K19F

** Iovance Biotherapeutics Inc IOVA.O:
BUZZ - Falls on Q1 revenue miss [nL4N41K19D ]

** Newmont Corp NEM.N:

** Gold Fields Ltd GFI.N:

** AngloGold Ashanti PLC AU.N:

** Harmony Gold Mining Co Ltd HMY.N:

BUZZ - Gold miners rise as bullion hits two-week high nL4N41K19L

** Entrada Therapeutics Inc TRDA.O:
BUZZ - Sinks after Duchenne drug underwhelms in early trial nL4N41K1AF

** AAON Inc AAON.O:
BUZZ - Surges on Q1 sales beat, forecast raise nL4N41K1AZ

** Cheniere Energy Inc LNG.N:
BUZZ - Falls after Q1 loss, tight supply warning nL4N41K1B4

** Prologis Inc PLD.N:
BUZZ - BMO upgrades Prologis to 'outperform' on data center demand nL4N41K1CD

** Moderna Inc MRNA.O:
BUZZ - Rises, study shows its mRNA flu vaccine outperforms standard shot nL4N41K1G9

** Atara Biotherapeutics Inc ATRA.O:
BUZZ - Jumps after US FDA backs re-submission of cancer drug application nL4N41K1E6

** Albemarle Corp ALB.N:
BUZZ - Gains after Q1 profit exceeds expectations nL4N41K1EJ

** Viatris Inc VTRS.O:
BUZZ - Rises after first-quarter results beat estimates nL4N41K1D1

** Howmet Aerospace Inc HWM.N:
BUZZ - Rises after raising annual revenue forecast nL4N41K1EY

** Travere Therapeutics Inc TVTX.O:
BUZZ - Climbs after upsized $475 mln convertible financing nL6N41K0W8

** Viridian Therapeutics Inc VRDN.O:
BUZZ - Drops on increased stock, convertible bond offerings nL6N41K0Y7

** Papa John's International Inc PZZA.O:
BUZZ - Down after Q1 revenue, profit miss nL6N41K0ZY

**Shake Shack Inc SHAK.N:
BUZZ - Sinks to over two-year low after quarterly loss nL6N41K0ZW

Index RIC	Index name	Percent change %
.SPX	S&P 500	0.1
.SPLRCT	S&P 500 Information Technology	0.99
.SPLRCU	S&P 500 Utilities	-0.86
.SPLRCD	S&P 500 Consumer Discretionary	0.11
.SPLRCM	S&P 500 Materials	-0.69
.SPLRCI	S&P 500 Industrials	-0.76
.SPLRCL	S&P 500 Communication Services (Sector)	0.18
.SPSY	S&P 500 Financials	-0.15
.SPLRCR	S&P 500 Real Estate	-0.6
.SPXHC	S&P 500 Health Care	-0.68
.SPLRCS	S&P 500 Consumer Staples	-0.44
.SPNY	S&P 500 Energy	-2.49