May 21 (Reuters) - Wall Street's main indexes fell on Thursday as oil prices surged following a Reuters report that Iran's Supreme ‌Leader Ayatollah Mojtaba Khamenei ordered the country's near-weapons-grade uranium not to be sent abroad, dimming hopes for progress in talks between Washington and Tehran. .N

At 11:30 EDT, the Dow Jones Industrial Average .DJI was down 0.22% at 49,897.25. The S&P 500 .SPX was down 0.37% at 7,405.54, and the Nasdaq Composite .IXIC was down 0.50% at 26,137.93.

The top three S&P 500 .PG.INX percentage gainers:

** Ralph Lauren Corp RL.N, up 11.9%

** Lumentum Holdings Inc LITE.OQ, up 9.3%

** International Business Machines Corp IBM.N, up 7.3%

The top three S&P 500 .PL.INX percentage losers:

** Intuit Inc INTU.OQ, down 19.8%

** Deere & Co DE.N, down 7.6%

** Walmart Inc WMT.OQ, down 7.6%

The top three NYSE .PG.N percentage gainers:

** Infleqtion Inc INFQ.N, up 32.2%

** D-Wave Quantum Inc QBTS.N, up 24.5%

** Advance Auto Parts Inc AAP.N, up 19.4%

The top three NYSE .PL.N percentage losers:

** Endava PLC DAVA.N, down 17.7%

** Borr Drilling Ltd BORR.N, down 14.2%

** Osisko Development Corp ODV.N, down 14.1%

The top three Nasdaq .PG.O percentage gainers:

** Co-Diagnostics Inc CODX.OQ, up 76.6%

** Netcapital Inc NCPL.OQ, up 76.3%

** Agape ATP Corp ATPC.OQ, up 62.7%

The top three Nasdaq .PL.O percentage losers:

** Digital Brands Group Inc DBGI.OQ, down 52.8%

** Hongli Group Inc HLP.OQ, down 32.2%

** Antelope Enterprise Holdings Ltd AEHL.OQ, down 31.6%

** Mobileye Global Inc MBLY.O:
BUZZ - Shares drop; Berenberg downgrades to 'hold' nL6N41Y0EH

** Elf Beauty Inc ELF.N:
BUZZ - Rises as quarterly sales and profit beat offsets forecast cut nL6N41Y0K1

** Walmart Inc WMT.O:
BUZZ - Drops after co keeps its annual targets intact after quarterly results beat nL6N41Y0PL

** Destiny Tech100 Inc DXYZ.N:
BUZZ - Rises after SpaceX makes IPO filing public nL6N41Y0M2

** International Business Machines Corp IBM.N:

** GlobalFoundries Inc GFS.O:

** D-Wave Quantum Inc QBTS.N:

** Rigetti Computing Inc RGTI.O:
BUZZ - Quantum computing stocks surge on $2 billion US award report nL4N41Y0WV

** Deere & Co DE.N:
BUZZ - Slips on quarterly profit fall nL4N41Y0SV

** Advance Auto Parts Inc AAP.N:
BUZZ - Jumps as quarterly earnings beat estimates nL4N41Y1EJ

** Osisko Development Corp ODV.N:
BUZZ - Tumbles on $275 mln convertible bond sale nL6N41Y0QM

** Eli Lilly and Co LLY.N:
BUZZ - Gains after data for next-generation weight loss drug nL4N41Y12T

** Iren Ltd IREN.O:

** Nebius Group NV NBIS.O:

** Coreweave Inc CRWV.O:
BUZZ - AI infrastructure firms climb after Nvidia's Q1 results nL6N41Y0SA

** Keysight Technologies Inc KEYS.N:
BUZZ - Barclays raises Keysight Technologies' PT on AI-led growth outlook nL4N41Y140

** Relay Therapeutics Inc RLAY.O:
BUZZ - Gains after $275 mln equity raise nL6N41Y0TE

** Ralph Lauren Corp RL.N:
BUZZ - Jumps on upbeat quarterly results nL6N41Y0UD

** American Healthcare REIT Inc AHR.N:
BUZZ - Falls on $706 mln equity offering nL6N41Y0V9

** Critical Metals Corp CRML.O:
BUZZ - Gains after deal with REalloys nL6N41Y0W9

** USA Rare Earth Inc USAR.O:
BUZZ - Gains on $19.3 million DOE funding nL4N41Y1D6

** Equity Residential EQR.N:

** AvalonBay Communities Inc AVB.N:
BUZZ - Fall after merger agreement nL4N41Y1DP

** BioMarin Pharmaceutical Inc BMRN.O:
BUZZ - Rises after genetic disorder drug meets main goal in trial nL4N41Y1DB

** GE HealthCare Technologies Inc GEHC.O:
BUZZ - UBS upgrades to "neutral" but sees risks lingering nL6N41Y0X3

** Nvidia Corp NVDA.O:
BUZZ - Bets on Vera CPUs and AI chips to boost 2026 revenue nL6N41Y0K7

** Tenet Healthcare Corp THC.N:

** HCA Healthcare Inc HCA.N:

** Universal Health Services Inc UHS.N:

BUZZ - Hospital operators fall as Medicaid agency proposes expansion of cuts to supplemental payments nL4N41Y1CK

** Intuit Inc INTU.O:
BUZZ - Hits 5-year low on weak forecast, layoffs nL4N41Y1EL

** Kroger Co KR.N:
BUZZ - Down after report of price cut plans nL6N41Y0XH

** Kontoor Brands Inc KTB.N:
BUZZ - Shares jump on Lee denim brand sale nL6N41Y0XV

** Centene Corp CNC.N:

** Molina Healthcare Inc MOH.N:
BUZZ - BofA sees earnings rebound for Centene, Molina if Medicaid margins improve nL4N41Y1HR

** Birkenstock Holding PLC BIRK.N:
BUZZ - Jumps on $250 million share buyback plan nL6N41Y0YW

** Blackstone Inc BX.N:
BUZZ - Worst of pressure may be behind for Blackstone's BCRED, TD Cowen says nL6N41Y0Z7

** Moderna Inc MRNA.O:
BUZZ - Falls after US FDA to hold expert panel meeting to review flu vaccine nL4N41Y1N3

Index RIC	Index name	Percent change %
.SPX	S&P 500	-0.37
.SPLRCT	S&P 500 Information Technology	-0.49
.SPLRCU	S&P 500 Utilities	0.78
.SPLRCD	S&P 500 Consumer Discretionary	-0.25
.SPLRCM	S&P 500 Materials	0.02
.SPLRCI	S&P 500 Industrials	-0.74
.SPLRCL	S&P 500 Communication Services (Sector)	0.09
.SPSY	S&P 500 Financials	-0.31
.SPLRCR	S&P 500 Real Estate	-0.37
.SPXHC	S&P 500 Health Care	0.18
.SPLRCS	S&P 500 Consumer Staples	-2.1
.SPNY	S&P 500 Energy	0.04