Celldex Therapeutics Presents Preclinical Data From Inflammatory Bispecific Antibody Program CDX-622 At AAAAI 2025; CDX-622 Inhibits SCF And TSLP-Dependent Inflammatory Signatures In Human Skin

Celldex Therapeutics, Inc.

Celldex Therapeutics, Inc.

CLDX

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- CDX-622 inhibits SCF and TSLP-dependent inflammatory signatures in human skin -

- Phase 1 study in healthy volunteers ongoing -

HAMPTON, N.J., March 03, 2025 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (NASDAQ:CLDX) announced today positive preclinical data from CDX-622, a novel bispecific antibody that targets two non-redundant, complementary pathways implicated in inflammation and fibrosis—thymic stromal lymphopoietin (TSLP) and mast cell depletion via stem cell factor (SCF) starvation.

The data demonstrate that CDX-622 neutralizes both SCF and TSLP, reducing tissue mast cells and inhibiting Type 2 inflammatory responses, supporting its potential to improve clinical activity over single target inhibition in inflammatory diseases and fibrotic disorders. The data were presented by Diego Alvarado, PhD, Vice President of Research at Celldex Therapeutics, in a poster presentation (#708) as part of the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting 2025.

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