Definium Therapeutics releases Phase 3 Emerge topline results presentation for DT120 in MDD

Definium Therapeutics, Inc.

Definium Therapeutics, Inc.

DFTX

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  • Definium Therapeutics published Phase 3 Emerge topline results for DT120 ODT in major depressive disorder.
  • Primary endpoint met, showing an 8.1-point MADRS improvement over placebo at week 6 (p<0.0001); 7.3 points at week 12 (p<0.0001).
  • Key secondary endpoint met, with a 0.9-point CGI-S improvement over placebo at day 2 (p<0.0001).
  • Safety profile showed no serious adverse events, no suicidality signal, no discontinuations; 99% reported a treatment-emergent adverse event.
  • Trial randomized 149 patients; single-dose DT120 ODT 100 micrograms versus placebo with outcomes tracked through 12 weeks.


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