Earnings Update: Septerna, Inc. (NASDAQ:SEPN) Just Reported Its First-Quarter Results And Analysts Are Updating Their Forecasts

Septerna

Septerna

SEPN

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As you might know, Septerna, Inc. (NASDAQ:SEPN) just kicked off its latest quarterly results with some very strong numbers. The results were impressive, with revenues of US$27m exceeding analyst forecasts by 76%, and statutory losses of US$0.19 were likewise much smaller than the analysts had forecast. Earnings are an important time for investors, as they can track a company's performance, look at what the analysts are forecasting for next year, and see if there's been a change in sentiment towards the company. So we gathered the latest post-earnings forecasts to see what estimates suggest is in store for next year.

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NasdaqGM:SEPN Earnings and Revenue Growth May 14th 2026

After the latest results, the eight analysts covering Septerna are now predicting revenues of US$87.9m in 2026. If met, this would reflect a substantial 22% improvement in revenue compared to the last 12 months. Losses are forecast to balloon 188% to US$2.30 per share. Yet prior to the latest earnings, the analysts had been forecasting revenues of US$65.7m and losses of US$1.94 per share in 2026. So there's been quite a change-up of views after the recent consensus updates, with the analysts significantly increasing their revenue forecasts while also expecting losses per share to increase. It looks like the top line growth will not be achieved without incremental costs.

There was no major change to the consensus price target of US$44.25, with growing revenues seemingly enough to offset the concern of growing losses. Fixating on a single price target can be unwise though, since the consensus target is effectively the average of analyst price targets. As a result, some investors like to look at the range of estimates to see if there are any diverging opinions on the company's valuation. Currently, the most bullish analyst values Septerna at US$60.00 per share, while the most bearish prices it at US$35.00. These price targets show that analysts do have some differing views on the business, but the estimates do not vary enough to suggest to us that some are betting on wild success or utter failure.

Of course, another way to look at these forecasts is to place them into context against the industry itself. We would highlight that Septerna's revenue growth is expected to slow, with the forecast 30% annualised growth rate until the end of 2026 being well below the historical 7,296% growth over the last year. Juxtapose this against the other companies in the industry with analyst coverage, which are forecast to grow their revenues (in aggregate) 8.7% per year. Even after the forecast slowdown in growth, it seems obvious that Septerna is also expected to grow faster than the wider industry.

The Bottom Line

The most important thing to take away is that the analysts increased their loss per share estimates for next year. Happily, they also upgraded their revenue estimates, and are forecasting them to grow faster than the wider industry. There was no real change to the consensus price target, suggesting that the intrinsic value of the business has not undergone any major changes with the latest estimates.

With that said, the long-term trajectory of the company's earnings is a lot more important than next year. At Simply Wall St, we have a full range of analyst estimates for Septerna going out to 2028, and you can see them free on our platform here..