Merck says Keytruda monotherapy improves PFS in Phase 3 trial for dMMR endometrial cancer

Merck & Co., Inc.

Merck & Co., Inc.

MRK

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  • Merck reported Phase 3 KEYNOTE-C93 met its primary endpoint, with Keytruda monotherapy improving PFS versus carboplatin-paclitaxel in dMMR advanced or recurrent endometrial cancer.
  • Interim overall survival analysis showed a favorable trend for Keytruda, though data were not mature; the trial continues with a future OS readout planned.
  • Trial enrolled 299 patients; Keytruda dosed 400 mg every six weeks for up to 18 cycles versus six cycles of platinum-doublet chemotherapy.
  • Merck plans to present results at a medical meeting, then share data with regulators; no new safety signals were identified.


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