Reported Saturday, BridgeBio Oncology Therapeutics Presents Preclinical Data Showing BBO-10203 Inhibits KRAS-Mutant Tumor Growth Without Inducing Hyperglycemia

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BridgeBio Oncology Therapeutics Inc. Ordinary Shares - Class A

BBOT

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Data demonstrate BBO-10203 blocks RAS-mediated activation of PI3Kα and strongly inhibits pAKT signaling in tumor cells without affecting glucose metabolism
Robust monotherapy activity, as well as combination activity with BBOT's KRASG12C ON/OFF inhibitor, BBO-8520, and panKRAS inhibitor, BBO-11818, was observed at well-tolerated dose levels in a panel of KRAS-mutant models
The combination of a KRAS inhibitor with a PI3Kα pathway inhibitor may maximize the response rate and reduce the development of adaptive resistance mechanisms due to full inhibition of both MAPK and PI3Kα signaling
BBOT-10203 is currently being evaluated in the Phase 1 BREAKER-101 trial for patients with HER2+ amplified or HR+/HER2- breast cancer, and KRAS mutant colorectal or non-small cell lung cancer with initial Phase 1 clinical data expected in the first half of 2026

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