Silexion Therapeutics presentation highlights SIL204 siRNA program targeting KRAS-driven pancreatic cancer

Biomotion Sciences. Ordinary Shares

Biomotion Sciences. Ordinary Shares

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  • Silexion outlined SIL204, an siRNA designed to silence KRAS gene expression with dual delivery targeting primary pancreatic tumors and micrometastases.
  • Program focus is locally advanced pancreatic cancer; KRAS mutations cited in 92% of cases, with SIL204 targeting more than 74% of PDAC KRAS mutations.
  • Total addressable market estimate for localized advanced pancreatic cancer: U.S. about USD 2 billion; E.U. about USD 3 billion.
  • Phase 2/3 trial plan: safety run-in to start mid-2026 with completion expected in Q2 2027; Phase 2 expansion to start Q3 2027.
  • Phase 3 confirmatory segment targeted to start Q3 2030; interim results flagged for 2028 with potential sample size adjustment.


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