Adds details from paragraph 2 onwards

May 5 (Reuters) - Devon Energy DVN.N missed Wall Street expectations for first-quarter profit on Tuesday, as lower production weighed on the U.S. shale producer's results.

First-quarter production fell to 387,000 barrels of oil equivalent per day (boepd), from 388,000 boepd a year earlier.

U.S. spot natural gas prices at the Waha Hub NG-WAH-WTX-SNL in the Permian Shale in West Texas have remained in negative territory for a record 61 days in a row as pipeline constraints trap gas in the Permian region, the nation's biggest oil-producing shale basin.

The Middle East conflict and resulting supply chain disruptions pushed oil prices LCOc1 up more than 88% this year, but producers have largely refrained from boosting output amid heightened geopolitical uncertainty.

For the second quarter, Devon expects production to be between 851,000 boepd and 868,000 boepd, and capital expenditure of $925 million.

The Oklahoma City-based company posted an adjusted profit of $1.04 per share for the three months ended March 31, compared with the analysts' average estimate of $1.06 per share, according to data compiled by LSEG.