Updates before market open

By Niket Nishant and Utkarsh Hathi

April 29 (Reuters) - Wall Street futures pointed to a mixed open for the indexes on Wednesday as investors treaded carefully ahead of several Big Tech earnings reports and a Federal Reserve meeting expected to be the last for Jerome Powell as its Chair.

Amazon AMZN.O, Meta Platforms META.O, Microsoft MSFT.O and Google-parent Alphabet GOOGL.O are set to report after the closing bell, when investors will gauge how their AI bets are paying off.

The results could shape investor confidence in one of the most resilient pockets of the financial markets, after sentiment was slightly dampened following a Wall Street Journal report that said OpenAI had missed its internal targets for weekly users and revenue, reviving fears about the AI spending spree of tech heavyweights.

"Tech has had an impressive rebound so far this quarter. The question now is whether mega-cap tech can help push this rally to new heights," said Bret Kenwell, U.S. investment analyst at eToro.

"Semiconductors have done much of the heavy lifting. There's clearly powerful momentum behind the group, but even the strongest rallies need time to reset."

The Philadelphia SE Semiconductor Index .SOX has gained 41.7% so far this year.

Amazon, Meta, Alphabet and Microsoft slipped between 0.3% and 0.5% in premarket trading.

At 8:43 a.m. ET, Nasdaq 100 E-minis NQcv1 gained 73.5 points, or 0.27%, S&P 500 E-minis EScv1 slipped 1.25 points, or 0.02%, and Dow E-minis YMcv1 fell 36 points, or 0.07%.

POWELL'S CURTAIN CALL?

Investors will also tune in to Fed Chair Jerome Powell's final press conference as the head of the U.S. central bank.

Republican Senator Thom Tillis dropped his objection to the Senate confirmation of ​Kevin Warsh, whom President Donald Trump had nominated to succeed Powell, after the Department of ​Justice ended ​an investigation ⁠into Powell that Tillis felt was a threat ​to the Fed's independence.

Traders expect the central bank to leave rates unchanged, but will closely parse Powell's remarks.

The Fed has said it was monitoring risks tied to the conflict, and with tensions in the Middle East showing few signs of easing, some investors worry policymakers may have to factor them more heavily into their outlook.

"While Powell's signals may be taken with some caution, given that this should be his last press conference, the risks are that he errs on the hawkish side," wrote ING Economics' FX strategist Francesco Pesole.

Iran's latest proposal for ending the two-month war would set aside discussion of its nuclear program until the conflict was concluded and shipping disputes resolved. Trump, however, said he was unhappy with the offer.

Meanwhile, major movers in the premarket session include online brokerage Robinhood Markets HOOD.O, which fell 11.6% after missing expectations for first-quarter profit.

Shares of data-storage companies climbed following an upbeat fourth-quarter forecast from Seagate Technology STX.O. Seagate jumped 15.9%, while peers Micron Technology MU.O, Sandisk SNDK.O and Western Digital WDC.O gained 4.8%, 6.4%, and 9.7%, respectively.

Coffee giant Starbucks SBUX.O rose 4.3% after raising its annual profit forecast.

Payments-processing firms Visa V.N and Mastercard MA.N added 5.6% and 2.6%, respectively, after Visa raised its forecast for full-year earnings.

NXP Semiconductors NXPI.O rose 21.2% after it said it expects second-quarter revenue and profit above Wall Street expectations.