Aptevo Therapeutics posts investor presentation on multispecific immunotherapies for cancer, led by mipletamig in AML

Aptevo Therapeutics, Inc.

Aptevo Therapeutics, Inc.

APVO

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  • Aptevo highlighted mipletamig in frontline AML with venetoclax-azacitidine, citing 81% CR/CRi and 65% CR in 31 patients.
  • Safety update showed no cytokine release syndrome through Cohort 5 in the RAINIER dose-optimization study; more than 120 patients treated across trials.
  • Development timeline targets recommended Phase 2 dose selection by year-end 2026; Phase 2 start in 1H27; first patient dosing in 2H27.
  • Niowave collaboration set as a 50/50 effort to develop up to three radiopharmaceutical programs, starting with a Nectin-4/actinium-225 target.
  • Pipeline emphasis included trispecific solid-tumor candidates such as APVO451; development candidate selection targeted by year-end 2026; IND-enabling studies in 1Q27.


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